Sntb1 Gene Summary [Rat]
Enables PDZ domain binding activity. Predicted to be located in cytoskeleton. Predicted to be part of dystrophin-associated glycoprotein complex. Predicted to be active in synapse. Orthologous to human SNTB1 (syntrophin beta 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sntb1 |
| Official Name | syntrophin, beta 1 [Source:RGD Symbol;Acc:1307728] |
| Ensembl ID | ENSRNOG00000004821 |
| Bio databases IDs | |
| Aliases | syntrophin, beta 1 |
| Synonyms | 59-DAP, A1B, BSYN2, DAPA1B, Dystrophin associated protein a1, LOC107986874, SNT2, SNT2B1, syntrophin, basic 1, Syntrophin beta 1, syntrophin, beta 1, Syntrophin β 1, syntrophin, β 1, TIP-43 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sntb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- myristoylation sequence
- PH domain
- canonical PDZ domain
- protein binding
- Pleckstrin homology-like domain
- PDZ domain
- PDZ-domain binding
Pathways
Biological processes and signaling networks where the Sntb1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- non-insulin-dependent diabetes mellitus
- preeclampsia
- lip and oral cavity carcinoma
- lip cancer
- overall survival
- small cell lung cancer
- pathologic myopia
- colorectal cancer
- refractive error
role in cell
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- microsome
- neuromuscular junctions
- synapse
- sarcolemma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sntb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle contraction
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- focal adhesion
- cytoplasm
- sarcolemma
- dystrophin-associated glycoprotein complex
- macromolecular complex
- synapse
- intracellular
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- protein binding
- actin binding
- PDZ domain binding
- structural molecule activity