Sipa1l2 Gene Summary [Rat]
Predicted to enable GTPase activator activity. Predicted to be involved in presynaptic signal transduction. Is active in glutamatergic synapse; postsynaptic density, intracellular component; and presynapse. Orthologous to human SIPA1L2 (signal induced proliferation associated 1 like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sipa1l2 |
| Official Name | signal-induced proliferation-associated 1 like 2 [Source:RGD Symbol;Acc:1306269] |
| Ensembl ID | ENSRNOG00000019791 |
| Bio databases IDs | |
| Aliases | signal-induced proliferation-associated 1 like 2 |
| Synonyms | mKIAA1389, Sersap2, signal-induced proliferation-associated 1 like 2, SPAL2, SPAR2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sipa1l2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rap/ran-GAP
- Domain present in PSD-95, Dlg, and ZO-1/2
- canonical PDZ domain
- protein binding
- C-terminal domain of SPAR protein
- PDZ domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- HER2 negative hormone receptor negative breast cancer
- Parkinson disease
- breast cancer
- shoulder impingement syndrome
- idiopathic scoliosis
- schizophrenia
- food allergy
role in cell
- long-term potentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- glutaminergic synapse
- organelle
- presynaptic regions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sipa1l2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of small GTPase mediated signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- GTPase activator activity