Tbr1 Gene Summary [Rat]
Enables protein kinase binding activity. Involved in cerebral cortex development. Predicted to be active in chromatin and nucleus. Orthologous to human TBR1 (T-box brain transcription factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tbr1 |
| Official Name | T-box brain transcription factor 1 [Source:RGD Symbol;Acc:1591773] |
| Ensembl ID | ENSRNOG00000005049 |
| Bio databases IDs | |
| Aliases | T-box brain transcription factor 1 |
| Synonyms | AUTS5, IDDAS, LOC100365364, LOC679107, T-box brain transcription factor 1, Tbrain 1, TES-56 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tbr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- T-box transcription factor-associated
- protein kinase binding
- nucleic acid binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- T-box
- double-stranded DNA binding
- CASK binding domain
- DNA-binding domain of the T-box transcription factor family
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- bipolar disorder
- hereditary disorder
- susceptibility to autism type 5
- intellectual developmental disorder with autism and speech delay
- mental retardation
- complex neurodevelopmental disorder
- intellectual developmental disorder with speech delay, autism, and dysmorphic facies
- marfanoid habitus with mental retardation
- neurodevelopmental disorder
role in cell
- apoptosis
- differentiation
- quantity
- migration
- formation
- function
- abnormal morphology
- remodeling
- guidance
- generation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tbr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- specification of organ identity
- commitment of neuronal cell to specific neuron type in forebrain
- amygdala development
- cerebral cortex development
- brain development
- positive regulation of transcription from RNA polymerase II promoter
- conditioned taste aversion
- regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- negative regulation of transcription, DNA-dependent
- hindbrain development
- gene expression
- regulation of neuron projection development
- cell fate specification
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- chromatin DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity