Pygo2 Gene Summary [Rat]
Predicted to enable chromatin binding activity; histone acetyltransferase regulator activity; and histone binding activity. Predicted to be involved in kidney development and spermatid nucleus differentiation. Predicted to act upstream of or within several processes, including canonical Wnt signaling pathway; lens development in camera-type eye; and regulation of mammary gland epithelial cell proliferation. Predicted to be located in nucleus. Predicted to be part of beta-catenin-TCF complex. Orthologous to human PYGO2 (pygopus family PHD finger 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pygo2 |
| Official Name | pygopus family PHD finger 2 [Source:RGD Symbol;Acc:1308535] |
| Ensembl ID | ENSRNOG00000020663 |
| Bio databases IDs | |
| Aliases | pygopus family PHD finger 2 |
| Synonyms | 1190004M21Rik, pygopus 2, pygopus family PHD finger 2, RGD1308535 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pygo2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- histone acetyltransferase regulator
- chromatin binding
- PHD finger superfamily
- protein binding
Pathways
Biological processes and signaling networks where the Pygo2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- exencephaly
- growth failure
- microphthalmia
- aphakia
role in cell
- migration
- expression in
- growth
- cell viability
- signaling in
- binding
- proliferation
- differentiation
- development
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pygo2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mammary gland development
- kidney development
- palate development
- spermatid nucleus differentiation
- regulation of mammary gland epithelial cell proliferation
- canonical Wnt receptor signaling pathway
- developmental growth
- brain development
- lens development in camera-type eye
Cellular Component
Where in the cell the gene product is active
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- histone acetyltransferase regulator activity
- protein binding
- histone binding
- metal ion binding
- chromatin binding