Nfix Gene Summary [Rat]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in several processes, including atrioventricular canal morphogenesis; nervous system development; and regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including learning or memory; myeloid leukocyte differentiation; and nervous system development. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Marshall-Smith syndrome and Sotos syndrome 2. Orthologous to human NFIX (nuclear factor I X). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nfix |
| Official Name | nuclear factor I X [Source:RGD Symbol;Acc:69080] |
| Ensembl ID | ENSRNOG00000002983 |
| Bio databases IDs | |
| Aliases | nuclear factor I X |
| Synonyms | CTF, MALNS, MRSHSS, NF1A, NF1-X, NF1/X, Nf1x1, NF-I/X, Nuclear factor 1/X, nuclear factor I X, nuclear factor I/X, SOTOS2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nfix often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- DNA binding domain
- nucleic acid binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- N-terminal Mad Homology 1 (MH1) domain
- Nuclear factor I protein pre-N-terminus
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- MH1 domain
- CTF/NF-I family transcription modulation region
- transcription factor activity
Pathways
Biological processes and signaling networks where the Nfix gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight loss
- Alzheimer disease
- Sotos syndrome 2
- Marshall-Smith syndrome
- non-insulin-dependent diabetes mellitus
- schizophrenia
- marfanoid habitus with mental retardation
- hereditary disorder
- scoliosis
- weight gain
role in cell
- apoptosis
- cell death
- growth
- expression in
- proliferation
- accumulation in
- recruitment in
- migration
- formation
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nfix gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- DNA replication
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity