Hus1 Gene Summary [Rat]
Predicted to be involved in several processes, including DNA integrity checkpoint signaling; DNA metabolic process; and cellular response to ionizing radiation. Predicted to act upstream of or within DNA damage checkpoint signaling; protein phosphorylation; and response to UV. Predicted to be located in nucleus. Predicted to be part of checkpoint clamp complex. Predicted to be active in site of double-strand break. Orthologous to human HUS1 (HUS1 checkpoint clamp component). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hus1 |
| Official Name | HUS1 checkpoint clamp component [Source:RGD Symbol;Acc:1591976] |
| Ensembl ID | ENSRNOG00000005141 |
| Bio databases IDs | |
| Aliases | HUS1 checkpoint clamp component |
| Synonyms | hHUS1, HUS1 checkpoint clamp component |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hus1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein binding
- Hus1-like protein
Pathways
Biological processes and signaling networks where the Hus1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- growth failure
- chorioallantoic membrane fusion failure
- Rett syndrome
role in cell
- expression in
- apoptosis
- cell death
- binding
- binding in
- damage
- DNA damage response
- breakage
- cohesion
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hus1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- embryo development ending in birth or egg hatching
- double-strand break repair via homologous recombination
- nucleotide-excision repair
- telomere maintenance
- response to UV
- response to DNA damage stimulus
- DNA damage checkpoint
- regulation of protein phosphorylation
- cellular response to ionizing radiation
- intra-S DNA damage checkpoint
- mitotic cell cycle DNA replication checkpoint
Cellular Component
Where in the cell the gene product is active
- nucleus
- site of double-strand break
- cytosol
- nucleolus
- nucleoplasm
- checkpoint clamp complex
Molecular Function
What the gene product does at the molecular level
- protein binding