Rad9a Gene Summary [Rat]
Predicted to enable 3'-5' exonuclease activity; SH3 domain binding activity; and enzyme binding activity. Predicted to be involved in DNA integrity checkpoint signaling; DNA repair; and cellular response to ionizing radiation. Predicted to act upstream of or within positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of checkpoint clamp complex. Orthologous to human RAD9A (RAD9 checkpoint clamp component A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rad9a |
| Official Name | RAD9 checkpoint clamp component A [Source:RGD Symbol;Acc:2319938] |
| Ensembl ID | ENSRNOG00000018729 |
| Bio databases IDs | |
| Aliases | RAD9 checkpoint clamp component A |
| Synonyms | RAD9, RAD9 checkpoint clamp component A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rad9a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3'-5' exonuclease
- protein kinase binding
- fxxlf motif
- Rad9
- enzyme binding
- histone deacetylase binding
- enzyme
- protein binding
- SH3-domain binding
- phosphorylation site
- BH3-like domain
- beta_clamp
- Caspase 3 cleavage site
- Bcl-2 homology 3 domain
- tail domain
Pathways
Biological processes and signaling networks where the Rad9a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- sporadic amyotrophic lateral sclerosis
- hepatocellular carcinoma
- liver cancer
- Waldenström macroglobulinemia
role in cell
- migration
- survival
- growth
- G2/M phase
- expression in
- proliferation
- apoptosis
- formation
- cell viability
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- intracellular membranes
- nuclear foci
- nucleoplasm
- PML nuclear bodies
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rad9a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA damage checkpoint
- DNA repair
- DNA replication checkpoint
- cellular response to ionizing radiation
- DNA damage response, signal transduction resulting in induction of apoptosis
- intra-S DNA damage checkpoint
- response to DNA damage stimulus
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- checkpoint clamp complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- 3'-5' exonuclease activity
- protein binding
- histone deacetylase binding
- double-stranded DNA specific 3'-5' exodeoxyribonuclease activity
- SH3 domain binding
- enzyme binding