Pde4d

Enables several functions, including beta-2 adrenergic receptor binding activity; cyclic-nucleotide phosphodiesterase activity; and signaling receptor regulator activity. Involved in several processes, including establishment of endothelial barrier; positive regulation of smooth muscle cell proliferation; and regulation of heart contraction. Located in centrosome and myofibril. Part of protein-containing complex. Used to study depressive disorder. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in acrodysostosis. Orthologous to human PDE4D (phosphodiesterase 4D). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pde4d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Pde4d gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Pde4d gene, providing context for its role in the cell.