Smcr8 Gene Summary [Rat]
Predicted to enable GTPase activator activity; protein kinase binding activity; and protein kinase inhibitor activity. Predicted to contribute to guanyl-nucleotide exchange factor activity. Predicted to be involved in negative regulation of gene expression; regulation of TOR signaling; and regulation of macroautophagy. Predicted to be located in several cellular components, including nucleoplasm; postsynapse; and presynapse. Predicted to be part of Atg1/ULK1 kinase complex and guanyl-nucleotide exchange factor complex. Orthologous to human SMCR8 (SMCR8-C9orf72 complex subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Smcr8 |
| Official Name | SMCR8-C9orf72 complex subunit [Source:RGD Symbol;Acc:1564621] |
| Ensembl ID | ENSRNOG00000005165 |
| Bio databases IDs | |
| Aliases | SMCR8-C9orf72 complex subunit |
| Synonyms | 2310076G09RIK, D030073L15RIK, DENND8A, RGD1564621, SMCR8-C9orf72 complex subunit, Smith-Magenis syndrome chromosome region, candidate 8 homolog (human) |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Smcr8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- protein kinase inhibitor activity
- guanyl-nucleotide exchange factor
- GTPase activator
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dextran sodium sulfate-induced colitis
- splenomegaly
- lymphadenopathy
role in cell
- expression in
- production in
- accumulation in
- maturation
- binding in
- hyperactivation
- ciliogenesis
- accumulation
- autophagy by
- exocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- presynaptic regions
- postsynaptic region
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Smcr8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression
- autophagy
- regulation of autophagy
- negative regulation of macroautophagy
- negative regulation of immune response
- positive regulation of TOR signaling cascade
- positive regulation of GTPase activity
- negative regulation of exocytosis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- guanyl-nucleotide exchange factor complex
- cell projection
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- guanyl-nucleotide exchange factor activity
- GTPase activator activity
- protein kinase inhibitor activity