Lamp1 Gene Summary [Rat]
Predicted to enable enzyme binding activity; ion channel inhibitor activity; and protein domain specific binding activity. Involved in autophagic cell death. Located in several cellular components, including cytoplasmic vesicle; lysosome; and neuronal cell body. Is active in glutamatergic synapse; postsynapse; and synaptic vesicle membrane. Orthologous to human LAMP1 (lysosomal associated membrane protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lamp1 |
| Official Name | lysosomal-associated membrane protein 1 [Source:RGD Symbol;Acc:2989] |
| Ensembl ID | ENSRNOG00000019629 |
| Bio databases IDs | |
| Aliases | lysosomal-associated membrane protein 1 |
| Synonyms | CD107a, LAMPA, LGP-120, LGP-A, lysosomal-associated membrane protein 1, P2B, Perk |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lamp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ion channel inhibitor
- cytoplasmic domain
- transmembrane/cytoplasmic domain
- Lysosome-associated membrane glycoprotein (Lamp)
- TM_EGFR-like
- enzyme binding
- protein domain specific binding
- protein binding
- cytosolic tail domain
Pathways
Biological processes and signaling networks where the Lamp1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- Alzheimer disease
- polycystic kidney disease
- Waldenström macroglobulinemia
- Niemann-Pick disease type C
- severe acute respiratory syndrome
- micrognathia
- astrocytosis
- early onset globoid cell leukodystrophy
- Hermansky-Pudlak syndrome type 2
role in cell
- differentiation
- morphology
- formation
- exocytosis
- fusion
- maturation
- cell death
- killing
- movement
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endosomal fractions
- lysosome fractions
- membrane fraction
- pH resistant lipid raft fraction
- synaptic vesicle membrane
- megasome
- prostasome
- glutaminergic synapse
- multivesicular domain
- endolysosomal tubule
- early endosome-associated tubule
- outer limiting lysosomal membrane
- Cytoplasm
- perinuclear Golgi regions
- cell surface
- perinuclear region
- postsynaptic region
- outer membranes
- membrane surface
- cellular membrane
- Nucleus
- vacuole
- endosomes
- vesicles
- lysosome
- membrane compartment
- immunological synapses
- secretory granule membrane
- granules
- cytoplasmic face of plasma membrane
- vesicle membrane
- plasma membrane extracellular face
- plasma membrane projections
- endosome-lysosome compartments
- lysosome membrane
- endosomal compartment
- endosomal membrane
- synaptic vesicles
- growth cone
- cytotoxic granule
- alveolar epithelial lamellar bodies
- sarcolemma
- autophagic vacuoles
- early endosomes
- late endosomes
- perinuclear vesicles
- cytoplasmic vesicles
- secretory vesicles
- endocytotic vesicle
- peripheral vesicles
- melanosomes
- multivesicular bodies
- autolysosomes
- endolysosomes
- membrane rafts
- perikaryon
- dendrites
- exosomes
- phagosomes
- phagocytic cups
- late endosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lamp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- establishment of protein localization to organelle
- viral entry into host cell
- lysosomal lumen acidification
- positive regulation of natural killer cell degranulation
- protein stabilization
- Golgi to lysosome transport
- positive regulation of natural killer cell mediated cytotoxicity
Cellular Component
Where in the cell the gene product is active
- synaptic vesicle
- late endosome
- external side of plasma membrane
- multivesicular body
- lysosomal membrane
- autophagic vacuole membrane
- plasma membrane
- lysosome
- late endosome membrane
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- melanosome
- cytoplasm
- sarcolemma
- membrane
- cytosol
- endosome membrane
- azurophil granule membrane
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- viral receptor activity
- ion channel inhibitor activity
- enzyme binding