Cst3 Gene Summary [Rat]
Enables peptidase inhibitor activity and protease binding activity. Involved in several processes, including Sertoli cell development; cellular response to hydrogen peroxide; and embryo implantation. Located in several cellular components, including multivesicular body; neuronal cell body; and nuclear membrane. Biomarker of intracranial aneurysm; iron deficiency anemia; and obesity. Human ortholog(s) of this gene implicated in CST3-related cerebral amyloid angiopathy and age related macular degeneration 11. Orthologous to human CST3 (cystatin C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cst3 |
| Official Name | cystatin C [Source:RGD Symbol;Acc:2432] |
| Ensembl ID | ENSRNOG00000005195 |
| Bio databases IDs | |
| Aliases | cystatin C |
| Synonyms | CYSC, cystatin C |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cst3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CY
- endopeptidase inhibitor
- cysteine protease inhibitor activity
- protease binding
- protease inhibitor
- beta-amyloid binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- Sjögren syndrome
- hyperplasia
- pancreatic cancer
- ischemic injury
- pancreatic epithelial cancer
- pancreatic neoplasia
- retroperitoneal cancer
role in cell
- proliferation
- production in
- activity
- loss
- response by
- synthesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- perinuclear region
- Plasma Membrane
- vesicles
- lysosome
- Golgi Apparatus
- nuclear envelope
- myofibrils
- multivesicular bodies
- cellular protrusions
- perikaryon
- axons
- basement membrane
- cytosolic fraction