Ctsb Gene Summary [Rat]
Enables several functions, including cysteine-type endopeptidase activity; identical protein binding activity; and kininogen binding activity. Involved in several processes, including cellular response to mechanical stimulus; response to dexamethasone; and response to kainic acid. Located in several cellular components, including caveola; external side of plasma membrane; and sarcolemma. Used to study hepatocellular carcinoma and high grade glioma. Biomarker of several diseases, including acute necrotizing pancreatitis; cerebrovascular disease (multiple); fascioliasis; renal tubular acidosis; and steatotic liver disease (multiple). Human ortholog(s) of this gene implicated in diabetes mellitus. Orthologous to human CTSB (cathepsin B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ctsb |
| Official Name | cathepsin B [Source:RGD Symbol;Acc:621509] |
| Ensembl ID | ENSRNOG00000010331 |
| Bio databases IDs | |
| Aliases | cathepsin B |
| Synonyms | AC270285.4, Alpha secretase, APPS, CATB, cathepsin B, CB, CPSB, KWE, RECEUP, α secretase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ctsb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptide binding
- occluding loop
- peptidase
- Peptidase_C1
- enzyme
- protein binding
- identical protein binding
- cathepsin B
- endopeptidase
- cysteine-type peptidase
- cysteine endopeptidase
- binding protein
- Peptidase family C1 propeptide
- collagen binding
- active site
Pathways
Biological processes and signaling networks where the Ctsb gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- rheumatoid arthritis
- schizophrenia
- epithelial cancer
- epithelial neoplasia
- cancer
- adenoma formation
- hyperglycemia
- insulin-dependent diabetes mellitus
- diabetes mellitus
role in cell
- cell death
- expression in
- proliferation
- phosphorylation in
- migration
- activation in
- apoptosis
- survival
- accumulation in
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- lysosome fractions
- insoluble fractions
- multivesicular domain
- ficolin-1-rich granule lumen
- cell surface
- cell borders
- Extracellular Space
- perinuclear region
- cellular membrane
- podosomes
- Nucleus
- endosomes
- vesicles
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum lumen
- microsome
- cisternae
- plasma membrane extracellular face
- apical membrane
- caveolae
- lysosomal compartment
- nuclear envelope
- nuclear matrix
- acrosome
- zymogen granules
- sarcolemma
- perinuclear vesicles
- secretory vesicles
- endocytotic vesicle
- azurophil granules
- secretory granules
- perikaryon
- phagosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ctsb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- cellular response to thyroid hormone stimulus
- epithelial cell differentiation
- thyroid hormone generation
- proteolysis
- collagen catabolic process
- decidualization
- regulation of apoptotic process
- proteolysis involved in cellular protein catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- melanosome
- endolysosome lumen
- external side of plasma membrane
- extracellular region
- apical plasma membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- collagen binding
- proteoglycan binding
- cysteine-type endopeptidase activity
- cysteine-type peptidase activity
- peptidase activity