Ctss Gene Summary [Rat]
Enables cysteine-type peptidase activity. Involved in bone resorption and metanephros development. Located in cell surface. Biomarker of intracranial aneurysm. Human ortholog(s) of this gene implicated in neuropathy. Orthologous to human CTSS (cathepsin S). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ctss |
| Official Name | cathepsin S [Source:RGD Symbol;Acc:621513] |
| Ensembl ID | ENSRNOG00000021157 |
| Bio databases IDs | |
| Aliases | cathepsin S |
| Synonyms | cathepsin S, CatS, CS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ctss often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cysteine-type peptidase
- cysteine endopeptidase
- Cathepsin propeptide inhibitor domain (I29)
- serine endopeptidase
- binding protein
- laminin binding
- peptidase
- cathepsin S
- Peptidase_C1
- collagen binding
- protein binding
- fibronectin binding
Pathways
Biological processes and signaling networks where the Ctss gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- hyperglycemia
- obesity
- epithelial neoplasia
- cancer
- cutaneous melanoma
- diabetes mellitus
- epithelial cancer
- allergic pulmonary eosinophilia
- chronic obstructive pulmonary disease
role in cell
- expression in
- molecular cleavage in
- apoptosis
- killing
- synthesis in
- migration
- degradation in
- injury
- activation
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- ficolin-1-rich granule lumen
- cell surface
- Extracellular Space
- organelle lumens
- cellular membrane
- podosomes
- endosomes
- lysosome
- granules
- lysosomal compartment
- endosomal compartment
- late endosomes
- phagosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ctss gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- extracellular matrix disassembly
- adaptive immune response
- cellular response to thyroid hormone stimulus
- toll-like receptor signaling pathway
- immune response
- proteolysis
- antigen processing and presentation of peptide antigen
- apoptotic process
- positive regulation of peptidase activity
- antigen processing and presentation
- positive regulation of cation channel activity
- collagen catabolic process
- protein processing
- response to acidity
- basement membrane disassembly
- antigen processing and presentation of exogenous peptide antigen via MHC class II
- proteolysis involved in cellular protein catabolic process
- positive regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- endolysosome lumen
- intracellular membrane-bounded organelle
- late endosome
- phagocytic vesicle
- lysosomal lumen
- extracellular region
- lysosome
Molecular Function
What the gene product does at the molecular level
- collagen binding
- proteoglycan binding
- fibronectin binding
- cysteine-type endopeptidase activity
- serine-type endopeptidase activity
- laminin binding
- cysteine-type endopeptidase activator activity involved in apoptotic process