Psap Gene Summary [Rat]
Predicted to enable several functions, including ganglioside binding activity; protein homodimerization activity; and scaffold protein binding activity. Predicted to be involved in several processes, including ganglioside GM1 transport to membrane; positive regulation of beta-galactosidase activity; and prostate gland development. Predicted to act upstream of or within with a negative effect on gene expression. Predicted to act upstream of or within several processes, including glycosylceramide metabolic process; nervous system development; and protein transport. Predicted to be located in aggresome; extracellular region; and late endosome. Predicted to be active in extracellular space and lysosome. Human ortholog(s) of this gene implicated in atypical Gaucher's disease due to saposin c deficiency; combined saposin deficiency; and late onset Parkinson's disease. Orthologous to human PSAP (prosaposin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Psap |
| Official Name | prosaposin [Source:RGD Symbol;Acc:3423] |
| Ensembl ID | ENSRNOG00000000571 |
| Bio databases IDs | |
| Aliases | prosaposin |
| Synonyms | Co-beta-glucosidase, Co-β-glucosidase, CSAct, Dispersin, GLBA, IPI00219825, PARK24, PROACTIVATOR POLYPEPTIDE precursor, Prosaposin, PSAPD, PSAP isoform 2, PSAP isoform 3, SAP1, SAP2, Saposin, SAPOSIN PROTEINS A-D, SGP-1, SGP1A, Sphingolipid activator |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Psap often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid antigen binding
- phospholipid binding
- sphingolipid binding
- lipid binding
- Saposin-like type B, region 2
- protease binding
- G-protein-coupled receptor binding
- Saposin (B) Domains
- protein binding
- enzyme activator activity
- identical protein binding
- Saposin A-type domain
- Saposin-like type B, region 1
- binding protein
- protein homodimerization
- glycosylation site
Pathways
Biological processes and signaling networks where the Psap gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- aortic valve calcification
- Parkinson disease
- Alzheimer disease
- saposin B deficiency
- prosaposin deficiency
- Tay-Sachs disease
- hyperactive behavior
- Duchenne muscular dystrophy
- hearing loss
- deficiency of arylsulfatase A
role in cell
- apoptosis
- expression in
- activation in
- accumulation in
- formation
- growth
- outgrowth
- activation
- cell viability
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- aggresome
- intracellular membrane-bounded organelle
- Cytoplasm
- perinuclear region
- cellular membrane
- Plasma Membrane
- lysosome
- Golgi Apparatus
- Mitochondria
- secretory granule membrane
- endosome-lysosome compartments
- lysosome membrane
- lysosomal compartment
- late endosomes
- endolysosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Psap gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- lysosomal transport
- regulation of autophagy
- prostate gland growth
- regulation of lipid metabolic process
- epithelial cell differentiation involved in prostate gland development
- sphingolipid metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- late endosome
- lysosomal lumen
- extracellular region
- azurophil granule membrane
- plasma membrane
- lysosomal membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- scaffold protein binding
- protein binding
- protein homodimerization activity
- protease binding
- enzyme activator activity
- phospholipid binding