Hnmt Gene Summary [Rat]
Enables histamine N-methyltransferase activity. Involved in several processes, including histamine metabolic process; response to cocaine; and response to interleukin-1. Predicted to be located in centrosome; cytoplasm; and nucleoplasm. Predicted to be active in cytosol. Used to study brain infarction. Human ortholog(s) of this gene implicated in Parkinson's disease; asthma; atopic dermatitis; autosomal recessive intellectual developmental disorder 51; and essential tremor. Orthologous to human HNMT (histamine N-methyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hnmt |
| Official Name | histamine N-methyltransferase [Source:RGD Symbol;Acc:71049] |
| Ensembl ID | ENSRNOG00000005223 |
| Bio databases IDs | |
| Aliases | histamine N-methyltransferase |
| Synonyms | 1500031F01Rik, histamine N-methyltransferase, HMT, HNMT-S1, HNMT-S2, MRT51 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hnmt often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- methyltransferase
- histamine N-methyltransferase
- enzyme
- AdoMet_MTases
- methyltransferase domain
- N-methyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- streptozotocin-induced diabetic nephropathy
- autosomal recessive mental retardation type 51
- uterine leiomyoma
- leiomyomatosis
- atopic dermatitis
- non-small cell lung carcinoma
- non-small cell lung cancer
- organismal death
- polyarticular juvenile rheumatoid arthritis
- susceptibility to asthma
regulates
- L-histidine
- histamine
- S-adenosylmethionine
role in cell
- lipotoxicity in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
- cytosol
- nucleoplasm
- membrane processes
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hnmt gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- histidine catabolic process
- respiratory gaseous exchange
- histamine metabolic process
- histamine catabolic process
- methylation
Cellular Component
Where in the cell the gene product is active
- centrosome
- extracellular vesicular exosome
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- histamine N-methyltransferase activity