Camk2b Gene Summary [Rat]
Enables calcium/calmodulin-dependent protein kinase activity; phospholipase binding activity; and protein kinase binding activity. A structural constituent of postsynaptic actin cytoskeleton. Involved in several processes, including cellular response to homocysteine; hippocampal neuron apoptotic process; and regulation of synapse organization. Acts upstream of or within long-term synaptic potentiation. Located in dendrite and perikaryon. Is active in glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 54. Orthologous to human CAMK2B (calcium/calmodulin dependent protein kinase II beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Camk2b |
| Official Name | calcium/calmodulin-dependent protein kinase II beta [Source:RGD Symbol;Acc:2262] |
| Ensembl ID | ENSRNOG00000052080 |
| Bio databases IDs | |
| Aliases | calcium/calmodulin-dependent protein kinase II beta |
| Synonyms | calcium/calmodulin-dependent protein kinase II beta, calcium/calmodulin-dependent protein kinase II, beta, Calcium/calmodulin dependent protein kinase ii delta, calcium/calmodulin-dependent protein kinase II β, calcium/calmodulin-dependent protein kinase II, β, Calcium/calmodulin dependent protein kinase ii δ, CAM2, CAMK2, Camk2 beta, Camk2 β, CAMKB, CaMKII, CAMKII beta, CAMKII β, CaM kinase II β, Ck2b, MRD54, β CaMK2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Camk2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase binding
- Protein tyrosine and serine/threonine kinase
- calmodulin binding domain
- enzyme binding
- SnoaL-like domain
- protein binding
- Protein kinase domain
- identical protein binding
- calmodulin regulated protein kinase
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- structural constituent of cytoskeleton
- protein homodimerization
- structural molecule
- NTF2_like
- Tyrosine kinase, catalytic domain
- calcium dependent protein serine/threonine kinase
Pathways
Biological processes and signaling networks where the Camk2b gene in rat plays a role, providing insight into its function and relevance in health or disease.
- B Cell Receptor Signaling
- Calcium Signaling
- Chemokine Signaling
- Circadian Rhythm Signaling
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Factors Promoting Cardiogenesis in Vertebrates
- Glioma Signaling
- GM-CSF Signaling
- GNRH Signaling
- HIF1α Signaling
- Melatonin Signaling
- Molecular Mechanisms of Cancer
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- Opioid Signaling Pathway
- PI3K Signaling in B Lymphocytes
- PKCθ Signaling in T Lymphocytes
- Protein Kinase A Signaling
- Reelin Signaling in Neurons
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NFAT in Cardiac Hypertrophy
- Serotonin Receptor Signaling
- Synaptic Long Term Potentiation
- Thrombin Signaling
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- osteoarthritis
- Alzheimer disease
- hereditary disorder
- autosomal dominant mental retardation type 54
- metabolic syndrome X
- ataxia
- mental retardation
- Huntington disease
- androgenic alopecia
role in cell
- survival
- quantity
- maturation
- signaling in
- long term synaptic depression
- thickness
- density
- plasticity
- outgrowth
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- postsynaptic density (PSD) fractions
- glutaminergic synapse
- endocytic vesicle membrane
- cell cortex
- Nucleus
- cytosol
- nucleoplasm
- dendritic spines
- sarcoplasmic reticulum membrane
- cortical actin filaments
- actin stress fibers
- filopodia
- central spindle
- perikaryon
- dendrites
- postsynaptic density
- presynaptic terminals
- actin cytoskeletal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Camk2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of synapse maturation
- positive regulation of dendritic spine morphogenesis
- signal transduction
- nervous system development
- regulation of dendritic spine development
- protein autophosphorylation
- protein phosphorylation
- regulation of long-term neuronal synaptic plasticity
- cell differentiation
- positive regulation of neuron projection development
- regulation of calcium ion transport
- regulation of skeletal muscle adaptation
- regulation of synapse structural plasticity
- regulation of neuron migration
Cellular Component
Where in the cell the gene product is active
- calcium- and calmodulin-dependent protein kinase complex
- centrosome
- cytoplasm
- cytosol
- synapse
- neuron projection
- endocytic vesicle membrane
- sarcoplasmic reticulum membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- calmodulin binding
- identical protein binding
- protein homodimerization activity
- protein binding
- actin binding
- calmodulin-dependent protein kinase activity
- calcium-dependent protein serine/threonine kinase activity