Itsn2 Gene Summary [Rat]
Predicted to enable molecular adaptor activity. Predicted to be involved in clathrin-dependent synaptic vesicle endocytosis and positive regulation of dendrite extension. Predicted to act upstream of or within cell-cell signaling and endocytosis. Predicted to be located in centrosome. Predicted to be active in cytosol; intracellular vesicle; and presynaptic membrane. Orthologous to human ITSN2 (intersectin 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Itsn2 |
| Official Name | intersectin 2 [Source:RGD Symbol;Acc:1590890] |
| Ensembl ID | ENSRNOG00000046741 |
| Bio databases IDs | |
| Aliases | intersectin 2 |
| Synonyms | Ese2, intersectin 2, mKIAA1256, PRO2015, SH3D1B, SH3P18, SWA, SWAP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Itsn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Coiled-coil region of CCDC155 or KASH
- Nuf2, DHR10-like domain
- Arginine and glutamate-rich 1
- coiled-coil domain
- Laminin Domain I
- Remorin, C-terminal region
- Dbl homology domain
- C2 domain
- Mitotic checkpoint protein
- Ezrin/radixin/moesin, alpha-helical domain
- Hyaluronan mediated motility receptor N-terminal
- EF-hand domain pair
- EFh
- protein binding
- Pleckstrin homology-like domain
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Spindle pole body component BBP1, C-terminal
- RhoGEF domain
- Src Homology 3 domain superfamily
- Domain of unknown function (DUF4659)
- RhoGEF
- Fez1
- Apg6 coiled-coil region
- MAP7 (E-MAP-115) family
- SynN
- Trichohyalin-plectin-homology domain
- Eps15 homology domain
- Pleckstrin homology domain
- Protein kinase C conserved region 2 (CalB)
- Coiled-coil domain-containing protein 66
Pathways
Biological processes and signaling networks where the Itsn2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- vascular dementia
- Alzheimer disease
- schizophrenia
- asthma
- endometriosis
- Waldenström macroglobulinemia
- infection by Dengue virus 2
role in cell
- extension
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
- cytosol
- endocytotic vesicle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Itsn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell differentiation
- endosomal transport
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- centrosome
- extracellular vesicular exosome
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- guanyl-nucleotide exchange factor activity
- binding, bridging