Slc38a1 Gene Summary [Rat]
Enables L-amino acid transmembrane transporter activity and amino acid:sodium symporter activity. Involved in several processes, including amino acid import; glutamine metabolic process; and positive regulation of L-glutamine import across plasma membrane. Located in external side of apical plasma membrane and neuronal cell body. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human SLC38A1 (solute carrier family 38 member 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc38a1 |
| Official Name | solute carrier family 38, member 1 [Source:RGD Symbol;Acc:69645] |
| Ensembl ID | ENSRNOG00000005291 |
| Bio databases IDs | |
| Aliases | solute carrier family 38, member 1 |
| Synonyms | AA409865, AL022800, ATA1, AU015942, GlnT, Gm32457, NAT2, Sa1, SAT1, SNAT1, solute carrier family 38 member 1, solute carrier family 38, member 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc38a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- neutral amino acid:sodium symporter
- glycine:sodium symporter
- alanine:sodium symporter
- glutamine transporter
- L-amino acid transporter
- sodium:amino acid transporter
- Solute carrier families 5 and 6-like; solute binding domain
- protein binding
- proline:sodium symporter
- amino acid transporter
- transporter
Pathways
Biological processes and signaling networks where the Slc38a1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- melanoma cancer
- Alzheimer disease
- melanoma
- gout
- facioscapulohumeral muscular dystrophy type 2
- Graves ophthalmopathy
- glioblastoma
- glioblastoma cancer
regulates
- GABA
- glutamine
- amino acids
- L-glutamine
- neutral amino acid
- neurotransmitter
role in cell
- proliferation
- colony formation
- senescence
- invasion by
- migration
- plasticity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- plasma membrane extracellular face
- basolateral membrane
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc38a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glutamine metabolic process
- female pregnancy
- amino acid transport
- gamma-aminobutyric acid biosynthetic process
- amino acid transmembrane transport
- glutamine transport
- alanine transport
- neurotransmitter uptake
- regulation of synaptic plasticity
- glycine transport
- neutral amino acid transport
- sodium ion transmembrane transport
- regulation of synaptic transmission, GABAergic
- amino acid import
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- neuronal cell body
- basolateral plasma membrane
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- L-amino acid transmembrane transporter activity
- protein binding
- glycine:sodium symporter activity
- neutral amino acid transmembrane transporter activity
- L-glutamine transmembrane transporter activity
- neutral amino acid:sodium symporter activity
- sodium:amino acid symporter activity
- amino acid transmembrane transporter activity
- proline:sodium symporter activity
- alanine:sodium symporter activity