Arid3a Gene Summary [Rat]
Predicted to enable several functions, including chromatin binding activity; identical protein binding activity; and transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; membrane raft; and nucleoplasm. Predicted to be active in nucleus. Orthologous to human ARID3A (AT-rich interaction domain 3A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arid3a |
| Official Name | AT-rich interaction domain 3A [Source:RGD Symbol;Acc:1305299] |
| Ensembl ID | ENSRNOG00000026435 |
| Bio databases IDs | |
| Aliases | AT-rich interaction domain 3A |
| Synonyms | AT-rich interaction domain 3A, BRIGHT, DRI1, DRIL1, DRIL3, DRX, E2FBP1, LOC687078, LOC690999 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Arid3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein interaction domain
- activation domain
- transcription regulator
- self-association domain
- tetramerization domain
- transcription cofactor
- chromatin binding
- protein binding
- identical protein binding
- ARID/BRIGHT DNA binding domain
- REKLES domain
- DNA binding
- REKLES beta domain
- ARID/BRIGHT DNA binding domain family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- atopic dermatitis
- systemic lupus erythematosus
- organismal death
- liver cancer
- rheumatoid arthritis
- COVID-19
- tumorigenesis
- hypoplasia
- juvenile dermatomyositis
role in cell
- expression in
- invasion by
- migration
- number
- growth
- proliferation
- differentiation
- senescence
- immortalization
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear matrix
- membrane rafts
- PML nuclear bodies
- plasma
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Arid3a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- membrane raft
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- identical protein binding
- transcription cofactor activity
- protein binding
- chromatin binding