Pwp1

Predicted to enable histone H4K20me3 reader activity and histone chaperone activity. Predicted to be involved in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I. Predicted to act upstream of or within negative regulation of DNA-templated transcription and positive regulation of stem cell differentiation. Predicted to be located in Golgi apparatus and nucleolus. Predicted to be active in nucleus. Orthologous to human PWP1 (PWP1 homolog, endonuclein). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pwp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Pwp1 gene, providing context for its role in the cell.