PWP1 Gene Summary [Human]
The protein encoded by this gene contains several WD-40 repeats and is found mostly in the nucleus. The expression and localization of this protein are cell cycle dependent. Expression of this gene is upregulated in pancreatic adenocarcinoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | PWP1 |
| Official Name | PWP1 homolog, endonuclein [Source:HGNC Symbol;Acc:HGNC:17015] |
| Ensembl ID | ENSG00000136045 |
| Bio databases IDs | |
| Aliases | PWP1 homolog, endonuclein, endonuclein |
| Synonyms | 2310058A11Rik, 2610205J09Rik, ENDONUCLEIN, IEF-SSP-9502, NCLB, PWP1 homolog, endonuclein, RGD1310705 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PWP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- protein binding activity, bridging
- WD domain, G-beta repeat
- WD40
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Golgi Apparatus
- Endoplasmic Reticulum
- nucleoplasm
- nucleoli
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PWP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of peptidyl-serine phosphorylation of STAT protein
- positive regulation of stem cell differentiation
- transcription, DNA-dependent
- rRNA processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- Golgi apparatus
- chromosome
- nucleolus