Traf3ip3 Gene Summary [Rat]
Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in cytoplasmic pattern recognition receptor signaling pathway and positive regulation of type I interferon production. Predicted to act upstream of or within several processes, including antiviral innate immune response; cellular response to cytokine stimulus; and positive regulation of type I interferon production. Predicted to be active in mitochondrial outer membrane. Orthologous to human TRAF3IP3 (TRAF3 interacting protein 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Traf3ip3 |
| Official Name | TRAF3 interacting protein 3 [Source:RGD Symbol;Acc:1304848] |
| Ensembl ID | ENSRNOG00000005565 |
| Bio databases IDs | |
| Aliases | TRAF3 interacting protein 3 |
| Synonyms | 6030423D04RIK, AI115021, RGD1304848, T3JAM, TRAF3 interacting protein 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Traf3ip3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CC1_SLMAP-like
- protein binding activity, bridging
- protein domain specific binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- androgenic alopecia
- systemic lupus erythematosus
- cleft palate
- cleft lip
- cleft palate with cleft lip
regulated by
- IFNGR1
- lipopolysaccharide
- Genome polyprotein
- dexamethasone
- Jurkat cells
- natural killer cells
- Immunoglobulin
- H2AB3
role in cell
- expression in
- production in
- activation in
- number
- phosphorylation in
- size
- generation
- quantity
- infiltration by
- endocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Mitochondria
- endoplasmic reticulum membrane
- Golgi membrane
- mitochondrial membrane
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Traf3ip3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoplasmic pattern recognition receptor signaling pathway
- positive regulation of type I interferon production
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- Golgi membrane
- mitochondrial outer membrane
- lysosomal membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein binding, bridging
- binding, bridging