Ntn4 Gene Summary [Rat]
Predicted to enable laminin-1 binding activity. Predicted to be involved in several processes, including axon guidance; basement membrane assembly; and substrate adhesion-dependent cell spreading. Predicted to act upstream of or within neuron remodeling and regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling. Predicted to be located in basement membrane. Predicted to be part of laminin complex. Orthologous to human NTN4 (netrin 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ntn4 |
| Official Name | netrin 4 [Source:RGD Symbol;Acc:1565947] |
| Ensembl ID | ENSRNOG00000005573 |
| Bio databases IDs | |
| Aliases | netrin 4 |
| Synonyms | netrin 4, PRO3091, RGD1565947 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ntn4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NTR_like
- Laminin-type epidermal growth factor-like domai
- Laminin N-terminal (Domain VI)
- laminin binding
- protein binding
- EGF_CA
- Laminin EGF domain
Pathways
Biological processes and signaling networks where the Ntn4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- allodynia
- COVID-19
- metastasis
- androgenic alopecia
- Hutchinson-Gilford progeria syndrome
- gout
- heat hyperalgesia
- colonic polyp
- pelvic organ prolapse
- gastroesophageal reflux
role in cell
- downregulation in
- phosphorylation in
- expression in
- activation in
- migration
- permeability
- proliferation
- sphere formation
- survival
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Plasma Membrane
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ntn4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- substrate adhesion-dependent cell spreading
- regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling
- basement membrane assembly
- axon guidance
- neuron remodeling
- cell migration
- tissue development
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- laminin complex
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- laminin-1 binding