NTN4
NTN4 Gene Summary
This gene encodes a member of the netrin family of proteins, which function in various biological processes including axon guidance, tumorogenesis, and angiogenesis. Netrins are laminin-related proteins that have an N-terminal laminin-type domain, epidermal growth factor-like repeat domain, and a positively charged heparin-binding domain at the C-terminus. The protein encoded by this gene is involved in processes including neurite growth and migration, angiogenesis and mural cell adhesion to endothelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]
Details
| Type | Protein Coding |
| Official Symbol | NTN4 |
| Official Name | netrin 4 [Source:HGNC Symbol;Acc:HGNC:13658] |
| Ensembl ID | ENSG00000074527 |
| Bio databases IDs | |
| Aliases | netrin 4, beta-netrin, Netrin-4 |
| Synonyms | netrin 4,PRO3091,RGD1565947 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NTR_like
- Laminin-type epidermal growth factor-like domai
- Laminin N-terminal (Domain VI)
- laminin binding
- protein binding
- EGF_CA
- Laminin EGF domain
Pathways
Biological processes and signaling networks where the NTN4 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CASK
- ENO1
- HOXA1
- MEOX2
- KRTAP5-9
- NTN4
- NXF1
- CYSRT1
- ITGB1
- BRAF
disease
- allodynia
- COVID-19
- metastasis
- androgenic alopecia
- Hutchinson-Gilford progeria syndrome
- gout
- heat hyperalgesia
- colonic polyp
- pelvic organ prolapse
- gastroesophageal reflux
regulated by
- cisplatin
- DSCAM
- CLIC1
- dexamethasone
- neural stem cells
- dsHIC1-2998
- oxygen
- FOXO3
- EXOSC5
- mir-21 (includes others)
regulates
- SRC (family)
- AKT
- PTK2
- ERK1/2
- RAC1
- MYC
- SRC
- p38 MAPK
- RHOA
- TJP1
role in cell
- downregulation in
- phosphorylation in
- expression in
- activation in
- migration
- permeability
- proliferation
- sphere formation
- survival
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Plasma Membrane
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the NTN4 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- substrate adhesion-dependent cell spreading
- regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling
- basement membrane assembly
- axon guidance
- neuron remodeling
- cell migration
- tissue development
- organ morphogenesis
CELLULAR COMPONENT
Where in the cell the gene product is active
- laminin complex
- extracellular region
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- laminin-1 binding