Frs2 Gene Summary [Rat]
Predicted to enable fibroblast growth factor receptor binding activity; neurotrophin TRKA receptor binding activity; and transmembrane receptor protein tyrosine kinase adaptor activity. Involved in cellular response to fibroblast growth factor stimulus and positive regulation of vascular associated smooth muscle cell proliferation. Predicted to be located in adherens junction and plasma membrane. Predicted to be active in cell-cell junction and cytoplasm. Orthologous to human FRS2 (fibroblast growth factor receptor substrate 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Frs2 |
| Official Name | fibroblast growth factor receptor substrate 2 [Source:RGD Symbol;Acc:1308201] |
| Ensembl ID | ENSRNOG00000005642 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor receptor substrate 2 |
| Synonyms | C330018A15Rik, fibroblast growth factor receptor substrate 2, FRS1A, FRS2A, FRS2-alpha, FRS2-α, SNT, SNT-1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Frs2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PTB domain (IRS-1 type)
- linker domain
- protein binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
- fibroblast growth factor receptor binding
- effector domain
- neurotrophin TRKA receptor binding
- phosphorylation site
- Grb2 binding domain
- myristoylation sequence
- phosphatase activator
- transmembrane receptor protein tyrosine kinase adaptor protein
- tyrosine phosphorylation site
- myristoylation signal domain
- SHP-2 binding domain
Pathways
Biological processes and signaling networks where the Frs2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- chronic obstructive pulmonary disease
- anophthalmia
- metastasis
- hyperplasia
- microphthalmia
- microalbuminuria
- growth failure
- atrial fibrillation
- infection by vesicular stomatitis virus
role in cell
- apoptosis
- activation in
- expression in
- growth
- proliferation
- migration
- differentiation
- colony formation
- cell cycle progression
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- raft fractions
- detergent resistant lipid raft fraction
- Cytoplasm
- cellular membrane
- intercellular junctions
- cytosol
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Frs2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- optic placode formation involved in camera-type eye formation
- anterior/posterior axis specification, embryo
- G-protein coupled receptor signaling pathway
- ventricular septum development
- transmembrane receptor protein tyrosine phosphatase signaling pathway
- fibroblast growth factor receptor signaling pathway
- regulation of apoptotic process
- prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
- positive regulation of MAPK cascade
- regulation of ERK1 and ERK2 cascade
- neuroblast proliferation
- forebrain development
- gastrulation with mouth forming second
- negative regulation of cardiac muscle cell differentiation
- organ induction
- regulation of epithelial cell proliferation
- lens fiber cell development
Cellular Component
Where in the cell the gene product is active
- adherens junction
- cell-cell junction
- cytoplasm
- membrane
- cytosol
- endomembrane system
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- phosphatase activator activity
- transmembrane receptor protein tyrosine kinase adaptor activity
- neurotrophin TRKA receptor binding
- fibroblast growth factor receptor binding