Fgf5 Gene Summary [Rat]
Enables growth factor activity. Predicted to be involved in several processes, including fibroblast growth factor receptor signaling pathway; positive regulation of MAPK cascade; and positive regulation of cell population proliferation. Predicted to act upstream of or within glial cell differentiation and signal transduction involved in regulation of gene expression. Predicted to be active in cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in familial isolated trichomegaly. Orthologous to human FGF5 (fibroblast growth factor 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fgf5 |
| Official Name | fibroblast growth factor 5 [Source:RGD Symbol;Acc:620129] |
| Ensembl ID | ENSRNOG00000022631 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor 5 |
| Synonyms | angora, Fgf3a, fibroblast growth factor 5, go, HBGF-5, Smag-82, TCMGLY |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fgf5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nerve growth factor receptor binding
- beta-trefoil_FGF
- fibroblast growth factor receptor binding
- growth factor
Pathways
Biological processes and signaling networks where the Fgf5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- glioblastoma
- glioblastoma cancer
- alopecia
- glioma formation
- male pattern hair loss
- androgenic alopecia
- colorectal cancer
- angina pectoris
- trichomegaly
role in cell
- differentiation
- expression in
- proliferation
- migration
- apoptosis
- morphology
- growth
- phosphorylation in
- survival
- tubulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fgf5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell proliferation
- signal transduction involved in regulation of gene expression
- nervous system development
- cell-cell signaling
- fibroblast growth factor receptor signaling pathway
- positive regulation of MAPK cascade
- organ morphogenesis
- positive regulation of cell division
- positive regulation of gene expression
- positive regulation of protein phosphorylation
- cell differentiation
- regulation of cell migration
- glial cell differentiation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- fibroblast growth factor receptor binding