Ndufa5 Gene Summary [Rat]
This nuclear gene encodes a conserved protein that comprises the B13 subunit of complex I of the mitochondrial respiratory chain. The encoded protein localizes to the inner mitochondrial membrane, where it is thought to aid in the transfer of electrons from NADH to ubiquinone. Alternative splicing results in multiple transcript variants. There are numerous pseudogenes of this gene on chromosomes 1, 3, 6, 8, 9, 11, 12, and 16. [provided by RefSeq, Apr 2014]
Details
| Type | Protein Coding |
| Official Symbol | Ndufa5 |
| Official Name | NADH:ubiquinone oxidoreductase subunit A5 [Source:RGD Symbol;Acc:3155] |
| Ensembl ID | ENSRNOG00000005698 |
| Bio databases IDs | |
| Aliases | NADH:ubiquinone oxidoreductase subunit A5 |
| Synonyms | 2900002J19Rik, B13, CI-13kB, CI-13KD-B, Complex i 13 kda subunit, NADH:ubiquinone oxidoreductase subunit A5, NADHUO, NUFM, UQOR13 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ndufa5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme
- protein binding
- NADH2 dehydrogenase (ubiquinone)
- ETC complex I subunit conserved region
Pathways
Biological processes and signaling networks where the Ndufa5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ndufa5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane transport
- mitochondrial electron transport, NADH to ubiquinone
- respiratory electron transport chain
- mitochondrial respiratory chain complex I assembly
- aerobic respiration
- mitochondrial ATP synthesis coupled proton transport
Cellular Component
Where in the cell the gene product is active
- respiratory chain complex I
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- NADH dehydrogenase (ubiquinone) activity