Galnt3 Gene Summary [Rat]
Predicted to enable calcium ion binding activity; manganese ion binding activity; and polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation via serine and protein O-linked glycosylation via threonine. Predicted to act upstream of or within several processes, including limb development; protein O-linked glycosylation; and skeletal system development. Predicted to be located in Golgi apparatus and perinuclear region of cytoplasm. Orthologous to human GALNT3 (polypeptide N-acetylgalactosaminyltransferase 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Galnt3 |
| Official Name | polypeptide N-acetylgalactosaminyltransferase 3 [Source:RGD Symbol;Acc:1306443] |
| Ensembl ID | ENSRNOG00000005727 |
| Bio databases IDs | |
| Aliases | polypeptide N-acetylgalactosaminyltransferase 3 |
| Synonyms | GalNAc-T3, HFTC, HFTC1, HHS, LOC102724230, polypeptide N-acetylgalactosaminyltransferase 3, Ppgantase t3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Galnt3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ricin-type beta-trefoil lectin domain
- Glycosyl transferase family 2
- Ricin-type beta-trefoil
- polypeptide N-acetylgalactosaminyltransferase
- N-terminal domain of galactosyltransferase
- calcium ion binding
- enzyme
- protein binding
- manganese ion binding
- glycosyltransferase family A
- ricin B-type lectin domain, beta-trefoil fold
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- familial hyperphosphatemic tumoral calcinosis type 1
- non-insulin-dependent diabetes mellitus
- hypercalcemia
- teratozoospermia
- growth failure
- Parkinson disease
- androgenic alopecia
- early missed abortion
- hyperphosphatemia
- uterine serous papillary cancer
role in cell
- accumulation in
- expression in
- apoptosis
- cell cycle progression
- differentiation
- quantity
- growth
- survival
- abnormal morphology
- endochondral ossification by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- Golgi Apparatus
- Golgi membrane
- Golgi stacks
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Galnt3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- protein O-linked glycosylation
- spermatogenesis
- protein O-linked glycosylation via serine
- protein O-linked glycosylation via threonine
- fibroblast growth factor receptor signaling pathway
- O-glycan processing
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- Golgi cisterna membrane
- membrane
- Golgi apparatus
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- calcium ion binding
- manganese ion binding
- carbohydrate binding
- polypeptide N-acetylgalactosaminyltransferase activity