Ivl Gene Summary [Rat]
Predicted to be involved in keratinocyte differentiation; peptide cross-linking; and response to UV-B. Predicted to act upstream of or within regulation of antibacterial peptide production. Predicted to be located in several cellular components, including centrosome; cornified envelope; and nuclear body. Orthologous to human IVL (involucrin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ivl |
| Official Name | involucrin [Source:RGD Symbol;Acc:620141] |
| Ensembl ID | ENSRNOG00000009314 |
| Bio databases IDs | |
| Aliases | involucrin |
| Synonyms | 1110019C06RIK, Involucrin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ivl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Involucrin
- Involucrin of squamous epithelia N-terminus
- protein binding
Pathways
Biological processes and signaling networks where the Ivl gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- benign neoplasia
- morbid obesity
- atopic dermatitis
- clear cell acanthoma
- skin neoplasia
- breast cancer
- androgenic alopecia
- Netherton syndrome
- senile lentigo
regulates
- IVL
- LORICRIN
- peptide
role in cell
- differentiation
- formation
- production
- cross-linkage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- cornified envelope
- interdesmosomal regions
- membrane surface
- centrosome
- Mitochondria
- desmosomes
- cytosol
- nuclear bodies
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ivl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- keratinocyte differentiation
- isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine
- peptide cross-linking
- keratinization
- response to UV-B
Cellular Component
Where in the cell the gene product is active
- centrosome
- cornified envelope
- nuclear body
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding