Tle1 Gene Summary [Rat]
Predicted to enable several functions, including chromatin binding activity; identical protein binding activity; and transcription corepressor activity. Predicted to be involved in negative regulation of anoikis; negative regulation of signal transduction; and regulation of gene expression. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of beta-catenin-TCF complex. Predicted to be active in nucleus. Orthologous to human TLE1 (TLE family member 1, transcriptional corepressor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tle1 |
| Official Name | TLE family member 1, transcriptional corepressor [Source:RGD Symbol;Acc:1309237] |
| Ensembl ID | ENSRNOG00000005882 |
| Bio databases IDs | |
| Aliases | TLE family member 1, transcriptional corepressor |
| Synonyms | ESG, ESG1, GRG1, GROUCHO 1, TLE family member 1, transcriptional corepressor, transducin-like enhancer of split 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tle1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SP repeat domain
- transcription regulator
- WD40 repeats
- Groucho/TLE N-terminal Q-rich domain
- transcription co-repressor
- WD domain, G-beta repeat
- transcription factor binding
- WD40
- chromatin binding
- protein binding
- glutamine-rich domain
- identical protein binding
Pathways
Biological processes and signaling networks where the Tle1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- non-insulin-dependent diabetes mellitus
- idiopathic scoliosis
- chronic obstructive pulmonary disease
- androgenic alopecia
- immunological disorder
- endometrial carcinoma
- epithelial endometrial cancer
- dental disorder
role in cell
- expression in
- growth
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tle1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- negative regulation of anoikis
- negative regulation of transcription, DNA-dependent
- signal transduction
- positive regulation of gene expression
- Wnt receptor signaling pathway
- negative regulation of Wnt receptor signaling pathway
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- transcription corepressor activity