Foxg1 Gene Summary [Rat]
Predicted to enable sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including neuron differentiation; positive regulation of neuroblast proliferation; and regulation of neuron differentiation. Predicted to be active in nucleus. Orthologous to human FOXG1 (forkhead box G1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Foxg1 |
| Official Name | forkhead box G1 [Source:RGD Symbol;Acc:2619] |
| Ensembl ID | ENSRNOG00000047891 |
| Bio databases IDs | |
| Aliases | forkhead box G1 |
| Synonyms | 2900064B05Rik, BF-1, BF1A, BF2, FHKL3, FKH2, FKHL1, FKHL2, FKHL3, FKHL4, forkhead box G1, FOXG1A, FOXG1B, FOXG1C, Foxo1, HBF-1, HBF-2, HBF-3, HBF-G2, Hfh9, Hfhbf1, HFK1, HFK2, HFK3, KHL2, QIN, RATBF1A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Foxg1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- FH_FOX
- double-stranded DNA binding
- protein binding
- loop domain
- sequence-specific DNA binding
- H helix
- DNA binding
- Forkhead domain
- FORKHEAD
Pathways
Biological processes and signaling networks where the Foxg1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- lymphomagenesis
- ovarian cancer
- clear cell ovarian cancer
- congenital variant Rett syndrome
- Rett syndrome
- FOXG1 syndrome
- hereditary disorder
- clear-cell ovarian carcinoma
- ovarian neoplasm
role in cell
- cell death
- proliferation
- expression in
- apoptosis
- quantity
- transformation
- survival
- cell cycle progression
- growth
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Mitochondria
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Foxg1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of neuron differentiation
- pyramidal neuron migration
- positive regulation of cell cycle
- positive regulation of neuron differentiation
- positive regulation of neuroblast proliferation
- brain development
- regulation of mitotic cell cycle
- dorsal/ventral pattern formation
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- neuroblast proliferation
- negative regulation of transcription, DNA-dependent
- neuron fate determination
- inner ear morphogenesis
- axon midline choice point recognition
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity