C1d Gene Summary [Rat]
Predicted to enable several functions, including DNA binding activity; nuclear receptor binding activity; and transcription corepressor activity. Predicted to be involved in maturation of 5.8S rRNA. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of transcription repressor complex. Orthologous to human C1D (C1D nuclear receptor corepressor). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | C1d |
| Official Name | C1D nuclear receptor corepressor [Source:RGD Symbol;Acc:1560600] |
| Ensembl ID | ENSRNOG00000005982 |
| Bio databases IDs | |
| Aliases | C1D nuclear receptor corepressor |
| Synonyms | 1110036E10Rik, C1D nuclear receptor co-repressor, hC1D, LRP1, RGD1560600, Rrp47, SUN-CoR |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat C1d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- ligand-dependent nuclear receptor interactor
- Sas10/Utp3/C1D family
- transcription co-repressor
- protein binding
- DNA binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- mucopolysaccharidosis, MPS-IV-A
- mucopolysaccharidosis type IVB
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat C1d gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maturation of 5.8S rRNA
- negative regulation of transcription, DNA-dependent
- apoptotic process
- regulation of gene expression
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear exosome (RNase complex)
- cytoplasm
- transcriptional repressor complex
- nucleolus
- nucleoplasm
- exosome (RNase complex)
Molecular Function
What the gene product does at the molecular level
- DNA binding
- ligand-dependent nuclear receptor binding
- RNA binding
- protein binding
- transcription corepressor activity