Sh3glb1 Gene Summary [Rat]
Predicted to enable several functions, including lysophosphatidic acid acyltransferase activity; phosphatidylinositol 3-kinase activator activity; and protein homodimerization activity. Involved in positive regulation of neurotrophin TRK receptor signaling pathway; regulation of cell morphogenesis; and regulation of early endosome to late endosome transport. Located in early endosome; neuronal cell body; and synaptic vesicle. Orthologous to human SH3GLB1 (SH3 domain containing GRB2 like, endophilin B1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sh3glb1 |
| Official Name | SH3 domain -containing GRB2-like endophilin B1 [Source:RGD Symbol;Acc:1304859] |
| Ensembl ID | ENSRNOG00000012957 |
| Bio databases IDs | |
| Aliases | SH3 domain -containing GRB2-like endophilin B1 |
| Synonyms | AU015566, Bif-1, CGI-61, dJ612B15.2, endophilin B1, mKIAA0491, PPP1R70, SH3 domain -containing GRB2-like endophilin B1, SH3 domain containing GRB2 like, endophilin B1, SH3-domain GRB2-like B1 (endophilin) |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sh3glb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lysophosphatidic acid acyltransferase
- fatty acid binding
- protein homodimerization
- enzyme
- BAR domain
- phosphoinositide 3-kinase regulator
- protein binding
- Bin/Amphiphysin/Rvs domain
- identical protein binding
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Sh3glb1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- primary melanoma
- melanoma cancer
- primary cancer
- organismal death
- mucopolysaccharidosis type IVB
- lymphocytic cancer
- survival
- astrocytosis
- melanoma
role in cell
- expression in
- proliferation
- signaling in
- depolarization
- cell death
- production in
- apoptosis
- activation in
- tubulation
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- mitochondrial envelope
- cellular membrane
- Mitochondria
- midbody
- cytosol
- nuclear bodies
- synaptic vesicles
- autophagic vacuoles
- early endosomes
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sh3glb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane organization
- membrane fission
- cellular response to amino acid starvation
- cellular response to glucose starvation
- positive regulation of autophagy
- receptor catabolic process
- regulation of protein stability
- autophagy
- autophagic cell death
- apoptotic process
- regulation of macroautophagy
- regulation of cytokinesis
- positive regulation of autophagic vacuole assembly
- positive regulation of protein complex assembly
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- cytoplasmic vesicle
- cytosol
- macromolecular complex
- Golgi membrane
- midbody
- mitochondrial outer membrane
- autophagic vacuole membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein homodimerization activity
- cadherin binding
- lipid binding