Rhoh Gene Summary [Rat]
Predicted to enable several functions, including GTP binding activity; GTPase activity; and kinase inhibitor activity. Predicted to be involved in several processes, including mast cell activation; negative regulation of canonical NF-kappaB signal transduction; and positive regulation of T cell differentiation. Predicted to be located in cytoplasm and immunological synapse. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 129. Orthologous to human RHOH (ras homolog family member H). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rhoh |
| Official Name | ras homolog family member H [Source:RGD Symbol;Acc:1307623] |
| Ensembl ID | ENSRNOG00000002540 |
| Bio databases IDs | |
| Aliases | ras homolog family member H |
| Synonyms | 5830400A04Rik, ARHH, AU019774, IMD129, ras homolog family member H, TTF |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rhoh often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- small GTP-binding protein domain
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- kinase inhibitor activity
- Rab subfamily of small GTPases
- enzyme
- protein binding
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
- Ras subfamily of RAS small GTPases
Pathways
Biological processes and signaling networks where the Rhoh gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Nucleation by ARP-WASP Complex
- Cholecystokinin/Gastrin-mediated Signaling
- CXCR4 Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- Glioblastoma Multiforme Signaling
- Glioma Invasiveness Signaling
- Gαq Signaling
- HMGB1 Signaling
- IL-8 Signaling
- ILK Signaling
- Integrin Signaling
- mTOR Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Regulation of Actin-based Motility by Rho
- RhoGDI Signaling
- Semaphorin Signaling in Neurons
- Serotonin Receptor Signaling
- Signaling by Rho Family GTPases
- Sphingosine-1-phosphate Signaling
- Tec Kinase Signaling
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- T acute lymphoblastic leukemia
- susceptibility to epidermodysplasia verruciformis type 4
- COVID-19
- Alzheimer disease
- hypoplasia
- diabetic nephropathy
- septic shock
- renal clear cell adenocarcinoma
- renal clear cell cancer
- androgenic alopecia
role in cell
- expression in
- proliferation
- quantity
- apoptosis
- activation in
- binding
- number
- activation
- differentiation
- positive selection
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- immunological synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rhoh gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T cell differentiation
- signal transduction
- small GTPase mediated signal transduction
- positive regulation of T cell differentiation
- actin filament organization
- regulation of transcription, DNA-dependent
- mast cell activation
- negative regulation of I-kappaB kinase/NF-kappaB cascade
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- plasma membrane
- immunological synapse
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein kinase binding
- protein binding
- GTPase inhibitor activity
- GTPase activity
- kinase inhibitor activity
- small GTPase binding