Tlk2 Gene Summary [Rat]
Predicted to enable ATP binding activity; identical protein binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including cellular response to gamma radiation; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and peptidyl-serine phosphorylation. Predicted to be located in intermediate filament. Predicted to be active in nucleus and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 57. Orthologous to human TLK2 (tousled like kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tlk2 |
| Official Name | tousled-like kinase 2 [Source:RGD Symbol;Acc:1310907] |
| Ensembl ID | ENSRNOG00000006285 |
| Bio databases IDs | |
| Aliases | tousled-like kinase 2 |
| Synonyms | 4933403M19RIK, HsHPK, MRD57, PKU-ALPHA, PKU-α, Tlk, Tlk2 predicted, tousled-like kinase 2, tousled-like kinase 2 (Arabidopsis) |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tlk2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- ATP binding
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
- identical protein binding
Pathways
Biological processes and signaling networks where the Tlk2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal dominant mental retardation type 57
- mental retardation
- hereditary disorder
- non-insulin-dependent diabetes mellitus
- developmental disorder
- neurodevelopmental disorder
- medulloblastoma
- brain cancer
role in cell
- number
- organization
- response by
- signal transduction in
- replication in
- DNA damage response
- segregation
- localization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- intermediate filaments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tlk2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to gamma radiation
- negative regulation of autophagy
- chromosome segregation
- protein phosphorylation
- chromatin organization
- response to DNA damage stimulus
- peptidyl-serine phosphorylation
- nucleus localization
- intracellular signal transduction
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- intermediate filament
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding
- protein serine/threonine kinase activity