Iqsec1 Gene Summary [Rat]
Predicted to enable protein kinase binding activity. Involved in positive regulation of synapse assembly; regulation of ARF protein signal transduction; and regulation of postsynaptic neurotransmitter receptor internalization. Predicted to be located in centrosome; cytosol; and nucleoplasm. Predicted to be active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density, intracellular component. Human ortholog(s) of this gene implicated in intellectual developmental disorder with short stature and behavioral abnormalities and lung adenocarcinoma. Orthologous to human IQSEC1 (IQ motif and Sec7 domain ArfGEF 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Iqsec1 |
| Official Name | IQ motif and Sec7 domain ArfGEF 1 [Source:RGD Symbol;Acc:1596313] |
| Ensembl ID | ENSRNOG00000060350 |
| Bio databases IDs | |
| Aliases | IQ motif and Sec7 domain ArfGEF 1 |
| Synonyms | ARF-GEP100, BRAG2, cI-43, D6Ertd349e, GEP100, IDDSSBA, IQ motif and Sec7 domain 1, IQ motif and Sec7 domain ArfGEF 1, KIAA0763, LOC108350819, LOC112267878 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Iqsec1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- serine-rich region
- protein kinase binding
- Sec7
- Sec7 domain
- IQ-like motif
- nuclear localization sequence
- PH domain
- protein binding
- Pleckstrin homology-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- overall survival
- covid-19 death
- non-insulin-dependent diabetes mellitus
- peripheral arterial disease
- ductal breast carcinoma
- ductal breast cancer
- intellectual developmental disorder with short stature and behavioral abnormalities
- postmenopausal osteoporosis
- infiltrating ductal breast carcinoma
role in cell
- migration
- invasiveness
- phagocytosis by
- development
- invasion
- disassembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- intracellular membrane-bounded organelle
- organelle
- cell periphery
- perinuclear region
- centrosome
- cytosol
- nucleoplasm
- nucleoli
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Iqsec1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of ARF protein signal transduction
- positive regulation of keratinocyte migration
- actin cytoskeleton organization
- dendritic spine development
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- synaptic vesicle
- intracellular membrane-bounded organelle
- membrane
- nucleolus
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity
- lipid binding