Sprr1b Gene Summary [Rat]
Predicted to be involved in keratinocyte differentiation and peptide cross-linking. Predicted to be located in cornified envelope. Orthologous to several human genes including SPRR1B (small proline rich protein 1B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sprr1b |
| Official Name | small proline-rich protein 1B [Source:RGD Symbol;Acc:1587862] |
| Ensembl ID | ENSRNOG00000031144 |
| Bio databases IDs | |
| Aliases | small proline-rich protein 1B |
| Synonyms | CORNIFIN, cornifin B, GADD33, small proline-rich protein 1B, SPR-IB, SPRR1, SQ37 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sprr1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cornifin (SPRR) family
- structural constituent of cytoskeleton
- structural molecule
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cornified envelope
- perinuclear region
- Golgi Apparatus
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sprr1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- keratinocyte differentiation
- epidermis development
- peptide cross-linking
- keratinization
Cellular Component
Where in the cell the gene product is active
- cornified envelope
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- structural molecule activity