Large2 Gene Summary [Rat]
Predicted to enable dystroglycan binding activity; glucuronosyltransferase activity; and xylosyltransferase activity. Predicted to be involved in protein O-linked mannosylation. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in Golgi apparatus. Orthologous to human LARGE2 (LARGE xylosyl- and glucuronyltransferase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Large2 |
| Official Name | LARGE xylosyl- and glucuronyltransferase 2 [Source:RGD Symbol;Acc:735214] |
| Ensembl ID | ENSRNOG00000006353 |
| Bio databases IDs | |
| Aliases | LARGE xylosyl- and glucuronyltransferase 2 |
| Synonyms | 5730485C17Rik, GYLTL1B, Largel, LARGE xylosyl- and glucuronyltransferase 2, mKIAA4105, PP5656 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Large2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyl-transferase for dystroglycan
- enzyme
- protein binding
- xylosyltransferase
- UDP-glycosyltransferase
- manganese ion binding
- glycosyltransferase
- Glycosyl transferase family 8
- glycosyltransferase family A
- glucuronosyltransferase
Pathways
Biological processes and signaling networks where the Large2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Large2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle cell homeostasis
- protein O-linked glycosylation
- protein O-linked mannosylation
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- protein binding
- xylosyltransferase activity
- UDP-xylosyltransferase activity
- glucuronosyltransferase activity
- manganese ion binding