Sdf2l1 Gene Summary [Rat]
Enables ATPase binding activity; misfolded protein binding activity; and protein-folding chaperone binding activity. Acts upstream of or within ERAD pathway; cellular response to misfolded protein; and regulation of apoptotic process. Located in endoplasmic reticulum and membrane. Used to study type 2 diabetes mellitus. Orthologous to human SDF2L1 (stromal cell derived factor 2 like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sdf2l1 |
| Official Name | stromal cell-derived factor 2-like 1 [Source:RGD Symbol;Acc:1585844] |
| Ensembl ID | ENSRNOG00000001859 |
| Bio databases IDs | |
| Aliases | stromal cell-derived factor 2-like 1 |
| Synonyms | LOC683036, Sdf211, SDF2L, stromal cell-derived factor 2-like 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sdf2l1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase binding
- MIR domain
- protein binding
- chaperone binding
- beta-trefoil_MIR
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sdf2l1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chaperone mediated protein folding requiring cofactor
- regulation of apoptotic process
- cellular response to misfolded protein
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- membrane
- endoplasmic reticulum
- endoplasmic reticulum chaperone complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- chaperone binding
- misfolded protein binding
- ATPase binding