Dag1 Gene Summary [Rat]
Enables laminin-1 binding activity. Involved in several processes, including calcium-dependent cell-matrix adhesion; nervous system development; and regulation of nervous system development. Located in several cellular components, including basolateral plasma membrane; costamere; and focal adhesion. Part of dystrophin-associated glycoprotein complex. Is active in glutamatergic synapse and postsynaptic cytosol. Used to study myocardial infarction. Biomarker of muscular atrophy; primary biliary cholangitis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in bronchopulmonary dysplasia and myopathy (multiple). Orthologous to human DAG1 (dystroglycan 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dag1 |
| Official Name | dystroglycan 1 [Source:RGD Symbol;Acc:621890] |
| Ensembl ID | ENSRNOG00000019400 |
| Bio databases IDs | |
| Aliases | dystroglycan 1 |
| Synonyms | 156DAG, A3a, AGRNR, alpha DG, D9Wsu13e, DAG, DG, Dp427, Dp71, Dystroglycan, dystroglycan 1, Dystroglycan beta, Dystroglycan precursor, Dystroglycan β, Dystrophin-associated glycoprotein-1, LGMDR16, MDDGA9, MDDGC7, MDDGC9, α DG, β-dystroglycan |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dag1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- viral receptor
- vinculin binding
- Dystroglycan-type cadherin-like domains
- membrane distal domain
- cytoplasmic domain
- tubulin binding
- actin binding
- Cadherin repeat-like domain
- membrane-proximal domain
- transmembrane receptor
- PPXY motif
- SH2-domain binding
- actinin binding
- Dystroglycan (Dystrophin-associated glycoprotein 1)
- X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins
- C-terminal domain of alpha dystroglycan
- protein binding
- ezrin binding domain
- proline tyrosine motif
- structural constituent of muscle
- serine endopeptidase
- binding protein
- laminin binding
- mucin domain
- cytosolic tail domain
Pathways
Biological processes and signaling networks where the Dag1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pain
- diabetes mellitus
- depressive disorder
- muscular dystrophy-dystroglycanopathy (limb-girdle) type C9
- Alzheimer disease
- demyelination
- muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies) type a9
- nonalcoholic fatty liver disease
- hydrocephalus
- cardiac fibrosis
role in cell
- expression in
- migration
- apoptosis
- formation
- binding in
- accumulation
- survival
- accumulation in
- organization
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- microsomal fraction
- soluble fraction
- membrane fraction
- pH resistant lipid raft fraction
- Golgi lumen
- dendrite tip
- rod photoreceptor terminal
- glutaminergic synapse
- glial endfeet
- intracellular membrane-bounded organelle
- intracellular compartment
- Cajal band
- postsynaptic invagination
- Cytoplasm
- cell-matrix contacts
- cell surface
- Extracellular Space
- intracellular space
- postsynaptic region
- outer membranes
- cellular membrane
- focal adhesions
- Nucleus
- contractile rings
- costameres
- intercellular junctions
- cell-cell contacts
- cytosol
- basal cell surfaces
- lateral cell surfaces
- basolateral cell surfaces
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- microsome
- membrane ruffles
- plasma membrane extracellular face
- caveolar membranes
- apical membrane
- postsynaptic membrane
- basolateral membrane
- Golgi membrane
- nucleoplasm
- nodes of Ranvier
- neuromuscular junctions
- synaptosomes
- synapse
- photoreceptor outer segments
- pedicels
- sarcolemma
- extracellular matrix
- basal lamina
- membrane rafts
- membrane processes
- microvilli
- filopodia
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
- ribbon synapse
- cell-cell adherens junctions
- plasma
- basement membrane
- lamellipodia
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dag1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- epithelial tube branching involved in lung morphogenesis
- microtubule anchoring
- negative regulation of MAPK cascade
- protein transport
- axon guidance
- branching involved in salivary gland morphogenesis
- positive regulation of oligodendrocyte differentiation
- skeletal muscle tissue regeneration
- nerve development
- regulation of epithelial to mesenchymal transition
- heart morphogenesis
- myelination in peripheral nervous system
- nerve maturation
- cellular response to cholesterol
- regulation of synaptic plasticity
- basement membrane organization
- regulation of embryonic cell shape
- commissural neuron axon guidance
- angiogenesis involved in wound healing
- response to denervation involved in regulation of muscle adaptation
- regulation of gastrulation
- response to muscle activity
- regulation of synapse organization
- morphogenesis of an epithelial sheet
- response to peptide hormone stimulus
- cellular response to mechanical stimulus
- membrane protein ectodomain proteolysis
- positive regulation of cell-matrix adhesion
- morphogenesis of an epithelium
- calcium-dependent cell-matrix adhesion
- negative regulation of cell migration
- muscle attachment
- axon regeneration
- positive regulation of myelination
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- extracellular region
- Golgi lumen
- nucleoplasm
- endoplasmic reticulum lumen
- basement membrane
- extracellular vesicular exosome
- focal adhesion
- postsynaptic membrane
- intracellular membrane-bounded organelle
- sarcolemma
- dystrophin-associated glycoprotein complex
- dystroglycan complex
- cytosol
- lamellipodium
- contractile ring
- costamere
- plasma membrane
- adherens junction
- extracellular space
- cytoskeleton
- cytoplasm
- membrane
- node of Ranvier
- filopodium
- nuclear periphery
- basolateral plasma membrane
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- alpha-actinin binding
- dystroglycan binding
- SH2 domain binding
- laminin-1 binding
- laminin binding
- structural constituent of muscle
- protein binding
- actin binding
- calcium ion binding
- vinculin binding
- viral receptor activity