Reg1a Gene Summary [Rat]
Enables growth factor activity; identical protein binding activity; and protein phosphatase binding activity. Involved in several processes, including cellular response to gastrin; liver regeneration; and positive regulation of epithelial cell proliferation. Located in several cellular components, including dendrite membrane; neuronal cell body membrane; and zymogen granule. Part of protein-containing complex. Biomarker of colon cancer and myocardial infarction. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to several human genes including REG1A (regenerating family member 1 alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Reg1a |
| Official Name | regenerating family member 1 alpha [Source:RGD Symbol;Acc:3552] |
| Ensembl ID | ENSRNOG00000006486 |
| Bio databases IDs | |
| Aliases | regenerating family member 1 alpha |
| Synonyms | LITHOST, PSP, PTP, RATLITHOST, RATRGPI, Reg, Reg1a, Reg1 alpha, Reg1 α, regenerating family member 1 alpha, regenerating family member 1 α, regenerating islet-derived 1, Rgp1, RGPI |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Reg1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- protein phosphatase binding
- Lectin C-type domain
- protein binding
- receptor binding
- identical protein binding
- growth factor
- phosphatase binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- basal compartment
- perinuclear region
- cellular membrane
- Plasma Membrane
- cytosol
- zymogen granules
- growth cone
- perikaryon
- dendrites