Reg1 Gene Summary [Mouse]
Predicted to enable several functions, including growth factor activity; identical protein binding activity; and peptidoglycan binding activity. Involved in several processes, including pancreas regeneration; phosphatidylinositol 3-kinase/protein kinase B signal transduction; and type B pancreatic cell differentiation. Acts upstream of or within with a positive effect on gene expression. Located in collagen-containing extracellular matrix. Is expressed in several structures, including esophagus; lung; and pancreas. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to several human genes including REG1A (regenerating family member 1 alpha). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Reg1 |
| Official Name | regenerating islet-derived 1 [Source:MGI Symbol;Acc:MGI:97895] |
| Ensembl ID | ENSMUSG00000059654 |
| Bio databases IDs | |
| Aliases | regenerating islet-derived 1 |
| Synonyms | LITHOST, PSP, PTP, RATLITHOST, RATRGPI, Reg, Reg1a, Reg1 alpha, Reg1 α, regenerating family member 1 alpha, regenerating family member 1 α, regenerating islet-derived 1, Rgp1, RGPI |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Reg1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- protein phosphatase binding
- Lectin C-type domain
- protein binding
- receptor binding
- identical protein binding
- growth factor
- phosphatase binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- basal compartment
- perinuclear region
- cellular membrane
- Plasma Membrane
- cytosol
- zymogen granules
- growth cone
- perikaryon
- dendrites