Psmb1 Gene Summary [Rat]
Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be located in nucleoplasm. Predicted to be part of proteasome core complex, beta-subunit complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human PSMB1 (proteasome 20S subunit beta 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Psmb1 |
| Official Name | proteasome 20S subunit beta 1 [Source:RGD Symbol;Acc:621092] |
| Ensembl ID | ENSRNOG00000001488 |
| Bio databases IDs | |
| Aliases | proteasome 20S subunit beta 1 |
| Synonyms | beta 1 PROTEASOME subunit, C5, C81484, HC5, Lmpc5, Macropain subunit C5, NEDMHAL, PMSB1, proteasome 20S subunit beta 1, proteasome 20S subunit β 1, proteasome (prosome, macropain) subunit, beta type 1, proteasome (prosome, macropain) subunit, β type 1, Proteasome Subunit C5, PSB1, PSC5, β 1 PROTEASOME subunit |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Psmb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ntn_hydrolase
- proteasome endopeptidase complex
- peptidase
- protein binding
- Proteasome subunit
Pathways
Biological processes and signaling networks where the Psmb1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- precursor B-cell acute lymphoblastic leukemia
- T acute lymphoblastic leukemia
- proteinuria
- non-insulin-dependent diabetes mellitus
- endometriosis
- refractory relapsed multiple myeloma
- refractory multiple myeloma
- liver cholangiocarcinoma
- progressive multiple myeloma
- plasma cell myeloma
role in cell
- activation in
- expression in
- cell death
- apoptosis
- quantity
- dipeptide repeat protein sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- Nucleus
- cytosol
- nucleoplasm
- clastosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Psmb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- proteolysis involved in cellular protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- proteasome core complex
- cytosol
- secretory granule lumen
- proteasome complex
- proteasome core complex, beta-subunit complex
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding