Srgap2 Gene Summary [Rat]
Predicted to enable GTPase activator activity; protein homodimerization activity; and small GTPase binding activity. Predicted to be involved in several processes, including plasma membrane bounded cell projection organization; substrate adhesion-dependent cell spreading; and synapse assembly. Located in cytoplasm and nucleus. Orthologous to human SRGAP2 (SLIT-ROBO Rho GTPase activating protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Srgap2 |
| Official Name | SLIT-ROBO Rho GTPase activating protein 2 [Source:RGD Symbol;Acc:1566016] |
| Ensembl ID | ENSRNOG00000006733 |
| Bio databases IDs | |
| Aliases | SLIT-ROBO Rho GTPase activating protein 2 |
| Synonyms | 9930124L22RIK, ARHGAP34, FBP2, FNBP2, LOC100132966, LOC440748, RGD1566016, SLIT-ROBO Rho GTPase activating protein 2, SRGAP2A, SRGAP3, WRP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Srgap2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- enzyme binding
- protein homodimerization
- Fes/CIP4, and EFC/F-BAR homology domain
- GTPase activator
- protein binding
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
- Bin/Amphiphysin/Rvs domain
- identical protein binding
- protein heterodimerization
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Srgap2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- non-insulin-dependent diabetes mellitus
- asthma
- diabetic nephropathy
- Dupuytren contracture
- cleft lip
regulates
- RAC1
- GTPase
role in cell
- outgrowth
- formation
- formation in
- differentiation
- development
- migration
- assembly
- migration by
- contact growth inhibition
- outgrowth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- Nucleus
- Plasma Membrane
- cytosol
- postsynaptic membrane
- dendritic spines
- dendritic spine head
- filopodia
- postsynaptic density
- phagosomes
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Srgap2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration
- signal transduction
- neuron projection morphogenesis
- lamellipodium assembly involved in ameboidal cell migration
- filopodium assembly
- positive regulation of GTPase activity
- dendritic spine development
- actin filament severing
- regulation of small GTPase mediated signal transduction
- substrate adhesion-dependent cell spreading
- negative regulation of cell migration
- negative regulation of neuron migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- postsynaptic density
- cytoplasm
- postsynaptic membrane
- phagocytic vesicle
- cytosol
- plasma membrane
- lamellipodium
- dendritic spine head
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein homodimerization activity
- protein binding
- GTPase activator activity
- small GTPase binding