Phldb2 Gene Summary [Rat]
Predicted to be involved in several processes, including negative regulation of focal adhesion assembly; regulation of cytoskeleton organization; and regulation of embryonic development. Predicted to be located in several cellular components, including cell leading edge; cytoskeleton; and focal adhesion. Predicted to be active in basal cortex. Orthologous to human PHLDB2 (pleckstrin homology like domain family B member 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Phldb2 |
| Official Name | pleckstrin homology-like domain, family B, member 2 [Source:RGD Symbol;Acc:1591402] |
| Ensembl ID | ENSRNOG00000002171 |
| Bio databases IDs | |
| Aliases | pleckstrin homology-like domain, family B, member 2 |
| Synonyms | C820004H04Rik, LL5b, LL5 beta, LL5 β, LOC100912785, LOC360713, NEWGENE 1591402, pleckstrin homology like domain family B member 2, pleckstrin homology-like domain, family B, member 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Phldb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPEC
- Ezrin/radixin/moesin, alpha-helical domain
- PH domain
- protein binding
- Pleckstrin homology-like domain
- Laminin Domain I
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atrial fibrillation
- eosinophilic esophagitis
- cleft palate
- cleft lip
- insulin-dependent diabetes mellitus
- Hutchinson-Gilford progeria syndrome
- uterine leiomyoma
- leiomyomatosis
- hemorrhoid
role in cell
- accumulation in
- formation
- formation in
- organization
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intermediate filament cytoskeleton
- cellular membrane
- focal adhesions
- podosomes
- cell cortex
- Plasma Membrane
- cytosol
- cell membrane leading edge
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Phldb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of focal adhesion assembly
- establishment of protein localization
- regulation of epithelial to mesenchymal transition
- regulation of gastrulation
- negative regulation of stress fiber assembly
- regulation of microtubule cytoskeleton organization
- establishment of cell polarity
- microtubule cytoskeleton organization
- cell migration
Cellular Component
Where in the cell the gene product is active
- intermediate filament cytoskeleton
- focal adhesion
- cell leading edge
- cytosol
- basal cortex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding