Prmt5 Gene Summary [Rat]
Predicted to enable several functions, including p53 binding activity; protein-arginine N-methyltransferase activity; and sequence-specific DNA binding activity. Involved in several processes, including liver regeneration; negative regulation of gene expression via chromosomal CpG island methylation; and positive regulation of oligodendrocyte differentiation. Part of protein-containing complex. Biomarker of asthma. Orthologous to human PRMT5 (protein arginine methyltransferase 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prmt5 |
| Official Name | protein arginine methyltransferase 5 [Source:RGD Symbol;Acc:1309053] |
| Ensembl ID | ENSRNOG00000012046 |
| Bio databases IDs | |
| Aliases | protein arginine methyltransferase 5 |
| Synonyms | HRMT1L5, HSL7, IBP72, JBP1, protein arginine methyltransferase 5, protein arginine N-methyltransferase 5, SKB1, SKB1Hs |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Prmt5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleic acid binding
- transcription co-repressor
- PRMT5 arginine-N-methyltransferase
- chromatin binding
- enzyme
- p53 binding
- protein binding
- protein-arginine N-methyltransferase
- sequence-specific DNA binding
- identical protein binding
- methyltransferase
- PRMT5 oligomerization domain
- histone methyltransferase
- binding protein
- PRMT5 TIM barrel domain
- double-stranded DNA binding
- methyl-CpG binding
- ribonucleoprotein binding
- tail domain
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Prmt5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal cancer
- polycythemia vera
- glioblastoma
- glioblastoma cancer
- myeloproliferative neoplasm
- myeloproliferative disorder
- breast adenocarcinoma
- lung cancer
- Epstein-Barr virus positive diffuse large B-cell lymphoma of the elderly
role in cell
- expression in
- number
- cell death
- proliferation
- apoptosis
- migration
- phosphorylation in
- invasion by
- quantity
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- Nucleus
- Golgi Apparatus
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Prmt5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endothelial cell activation
- regulation of mitosis
- regulation of transcription, DNA-dependent
- hypermethylation of CpG island
- transcription termination, DNA-dependent
- Golgi ribbon formation
- positive regulation of oligodendrocyte differentiation
- spliceosomal snRNP assembly
- regulation of ERK1 and ERK2 cascade
- circadian regulation of gene expression
- chromatin remodeling
- negative regulation of transcription, DNA-dependent
- negative regulation of cell differentiation
- positive regulation of nuclear mRNA splicing, via spliceosome
- peptidyl-arginine N-methylation
- peptidyl-arginine methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- histone methyltransferase complex
- methylosome
- cytosol
- Golgi apparatus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein-arginine omega-N symmetric methyltransferase activity
- identical protein binding
- methyltransferase activity
- methyl-CpG binding
- histone-arginine N-methyltransferase activity
- p53 binding
- protein binding
- transcription corepressor activity
- protein heterodimerization activity
- histone methyltransferase activity (H4-R3 specific)
- histone methyltransferase activity
- ribonucleoprotein complex binding
- protein-arginine N-methyltransferase activity
- E-box binding