Htr3b Gene Summary [Rat]
Enables serotonin-gated monoatomic cation channel activity. Involved in cellular response to growth factor stimulus and positive regulation of ion transmembrane transporter activity. Located in axon and neuronal cell body. Human ortholog(s) of this gene implicated in alcohol use disorder and depressive disorder. Orthologous to human HTR3B (5-hydroxytryptamine receptor 3B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Htr3b |
| Official Name | 5-hydroxytryptamine receptor 3B [Source:RGD Symbol;Acc:61820] |
| Ensembl ID | ENSRNOG00000006920 |
| Bio databases IDs | |
| Aliases | 5-hydroxytryptamine receptor 3B |
| Synonyms | 5-HT3B, 5-hydroxytryptamine receptor 3B, 5-hydroxytryptamine (serotonin) receptor 3B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Htr3b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- LGIC_ECD
- neurotransmitter receptor
- transmembrane domain of Cys-loop neurotransmitter-gated ion channels
- channel/pore class transporter
- Neurotransmitter-gated ion-channel ligand binding domain
- ligand-gated ion channel
- extracellular ligand-gated ion channel
- Cation transporter family protein
- ion channel
- transmembrane receptor
- cation channel
Pathways
Biological processes and signaling networks where the Htr3b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- SLC15A4
- mirtazapine
- alosetron
- fenfluramine
- granisetron
- cisapride
- palonosetron
- ergotamine
- ondansetron
- dolasetron
disease
- vomiting
- nausea and vomiting
- epithelial cancer
- cancer
- prostate cancer
- lung cancer
- pain
- metastasis
- postoperative nausea
- nausea
regulates
- Ca2+
- inorganic cation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Htr3b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of excitatory postsynaptic membrane potential
- regulation of membrane potential
- ion transmembrane transport
- synaptic transmission
- serotonin receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- postsynaptic membrane
- synapse
- neuron projection
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- excitatory extracellular ligand-gated ion channel activity
- serotonin-gated cation channel activity