Ric3 Gene Summary [Rat]
Enables acetylcholine receptor binding activity. Acts upstream of or within cholinergic synaptic transmission and positive regulation of cytosolic calcium ion concentration. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in intracellular membrane-bounded organelle; neuron projection; and neuronal cell body. Orthologous to human RIC3 (RIC3 acetylcholine receptor chaperone). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ric3 |
| Official Name | RIC3 acetylcholine receptor chaperone [Source:RGD Symbol;Acc:1588939] |
| Ensembl ID | ENSRNOG00000014691 |
| Bio databases IDs | |
| Aliases | RIC3 acetylcholine receptor chaperone |
| Synonyms | AYST720, E130307J04RIK, PRO1385, RIC3 acetylcholine receptor chaperone |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ric3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Resistance to inhibitors of cholinesterase homolog 3
- signal peptide
- coiled-coil domain
- protein binding
- receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cell surface
- perinuclear region
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ric3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization at cell surface
- synaptic transmission, cholinergic
- positive regulation of protein localization at cell surface
- macromolecular complex assembly
- protein folding
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- intracellular membrane-bounded organelle
- Golgi membrane
- neuronal cell body
- synapse
- neuron projection
Molecular Function
What the gene product does at the molecular level
- protein binding involved in protein folding
- acetylcholine receptor binding