C3 Gene Summary [Rat]
Enables lipid binding activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; response to estradiol; and response to progesterone. Located in extracellular space. Used to study glomerulonephritis; membranous glomerulonephritis; obesity; pneumonia; and pre-eclampsia. Biomarker of several diseases, including artery disease (multiple); cerebrovascular disease (multiple); eye disease (multiple); liver disease (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including complement deficiency (multiple); macular degeneration (multiple); paroxysmal nocturnal hemoglobinuria; sickle cell anemia; and silicosis. Orthologous to human C3 (complement C3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | C3 |
| Official Name | complement C3 [Source:RGD Symbol;Acc:2232] |
| Ensembl ID | ENSRNOG00000046834 |
| Bio databases IDs | |
| Aliases | complement C3 |
| Synonyms | ACYLATION STIMULATING, AHUS5, ARMD9, ASP, circC3, circRNA-C3, Complement c3, complement component 3, CPAMD1, HEL-S-62p, HSE-MSF, Plp |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat C3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Alpha-2-macroglobulin bait region domain
- lipid binding
- Macroglobulin domain MG4
- peptidase
- G-protein-coupled receptor binding
- A-macroglobulin receptor binding domain
- classical-complement-pathway C3/C5 convertase
- protein binding
- receptor binding
- Macroglobulin domain MG3
- NTR_like
- ISOPREN_C2_like
- A-macroglobulin TED domain
- complement component 3 convertase cleavage site
- Macroglobulin domain MG1
- receptor agonist activity
- ANATO
- Alpha-2-macroglobulin family
- MG2 domain
Pathways
Biological processes and signaling networks where the C3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dextran sodium sulfate-induced colitis
- pituitary gland adenoma
- schizophrenia
- weight gain
- choroidal neovascularization
- glycogen storage disease type II
- osteoarthritis
- arthritis
- preeclampsia
- septic shock
role in cell
- binding
- chemotaxis
- expression in
- apoptosis
- activation in
- phosphorylation in
- proliferation
- cell viability
- loss
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- late endoplasmic reticulum derived secretory vesicle
- early endoplasmic reticulum derived secretory vesicle
- secretory granule lumen
- azurophil granule lumen
- Cytoplasm
- cell surface
- intracellular space
- cellular membrane
- Nucleus
- Plasma Membrane
- vesicles
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum lumen
- exosomes
- plasma
- basement membrane
- glomerular basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat C3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of phagocytosis, engulfment
- positive regulation of angiogenesis
- positive regulation of activation of membrane attack complex
- positive regulation of G-protein coupled receptor protein signaling pathway
- complement activation
- complement activation, alternative pathway
- beta-amyloid clearance
- inflammatory response
- immune response
- complement activation, classical pathway
- positive regulation of receptor-mediated endocytosis
- positive regulation vascular endothelial growth factor production
- G-protein coupled receptor signaling pathway
- signal transduction
- complement receptor mediated signaling pathway
- fatty acid metabolic process
- positive regulation of glucose transport
- positive regulation of apoptotic cell clearance
- complement-dependent cytotoxicity
- response to bacterium
- positive regulation of type IIa hypersensitivity
- positive regulation of protein phosphorylation
- regulation of triglyceride biosynthetic process
- oviduct epithelium development
- neuron remodeling
- positive regulation of lipid storage
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
- blood microparticle
- macromolecular complex
- secretory granule lumen
- extracellular region
- azurophil granule lumen
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- C5L2 anaphylatoxin chemotactic receptor binding
- endopeptidase inhibitor activity
- protein binding
- receptor binding