Ccn4 Gene Summary [Rat]
Predicted to enable heparin binding activity and integrin binding activity. Involved in positive regulation of cell growth involved in cardiac muscle cell development; positive regulation of smooth muscle cell migration; and positive regulation of smooth muscle cell proliferation. Predicted to be located in cytosol. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human CCN4 (cellular communication network factor 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Ccn4 |
| Official Name | cellular communication network factor 4 [Source:RGD Symbol;Acc:69431] |
| Ensembl ID | ENSRNOG00000007078 |
| Bio databases IDs | |
| Aliases | cellular communication network factor 4 |
| Synonyms | cellular communication network factor 4, Elm1, WISP1, WISP1c, WISP1i, WISP1-OT1, WISP1tc, WISP1-UT1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ccn4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Glycoprotein hormone beta chain homologues
- Thrombospondin type 1 domain
- von Willebrand factor type C domain
- protein binding
- Spondin-like TSP1 domain
- Insulin-like growth factor binding protein
Pathways
Biological processes and signaling networks where the Ccn4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- autoimmune disease
- acute myeloid leukemia
- neoplasia
- ovarian cancer
- endometriosis
- colorectal cancer
- organismal death
- metastasis
- cutaneous melanoma cancer
role in cell
- expression in
- phosphorylation in
- apoptosis
- growth
- production in
- proliferation
- cell death
- number
- colony formation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ccn4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of wound healing
- signal transduction
- positive regulation of inflammatory response
- negative regulation of fat cell differentiation
- cell-cell signaling
- cell adhesion
- positive regulation of cell differentiation
- positive regulation of osteoblast differentiation
- bone development
- osteoclast differentiation
- positive regulation of smooth muscle cell proliferation
- glucose homeostasis
- osteoblast differentiation
- Wnt receptor signaling pathway
- negative regulation of chondrocyte differentiation
- positive regulation of Wnt receptor signaling pathway
- regulation of cytokine production
- positive regulation of smooth muscle cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytosol
- extracellular matrix
Molecular Function
What the gene product does at the molecular level
- protein binding
- heparin binding
- integrin binding